Which cancer is derived from skeletal (striated) muscle?

Which cancer is derived from skeletal (striated) muscle?

• A. Hodgkin's lymphoma
• B. Rhabdomyosarcoma
• C. Melanoma
• D. Hemangiosarcoma

Answer: (B)

Identifying a malignancy that originates from skeletal (striated) muscle is the key concept. Rhabdomyosarcoma is the cancer that arises from primitive skeletal muscle cells (rhabdomyoblasts) and shows skeletal muscle differentiation. This makes it the correct choice because its lineage is directly tied to skeletal muscle tissue, unlike other cancers that come from different cell types. In practice, rhabdomyosarcoma often demonstrates markers of muscle lineage, such as desmin and myogenin, confirming its skeletal muscle origin. Hodgkin's lymphoma comes from B cells in the lymphatic system, melanoma from pigment-producing melanocytes, and hemangiosarcoma from endothelial cells lining blood vessels.

Identifying a malignancy that originates from skeletal (striated) muscle is the key concept. Rhabdomyosarcoma is the cancer that arises from primitive skeletal muscle cells (rhabdomyoblasts) and shows skeletal muscle differentiation. This makes it the correct choice because its lineage is directly tied to skeletal muscle tissue, unlike other cancers that come from different cell types. In practice, rhabdomyosarcoma often demonstrates markers of muscle lineage, such as desmin and myogenin, confirming its skeletal muscle origin.

Hodgkin's lymphoma comes from B cells in the lymphatic system, melanoma from pigment-producing melanocytes, and hemangiosarcoma from endothelial cells lining blood vessels.